Implementation
Python

Be concise.

Be useful.

All contributions dictatorially edited by webmasters to match personal tastes.

Please do not paste any copyright violating resource.

Please try to avoid dependencies to third-party libraries and frameworks.

Other implementations
import "io/ioutil"
dir, err := ioutil.TempDir("", "")
string mkTmpDir()
{
    import std.uuid, std.file, std.path;
    string d = buildPath(tempDir, randomUUID.toString);
    if (!d.exists)
    {
        mkdir(d);
        return d;
    }
    else return null;
}

string s;
while (!s.length)
  s = mkTmpDir;
require 'tmpdir' 
td = Dir.mktmpdir
sysutils
var
  GUID: TGUID;
  Succes: Boolean;

begin
  CreateGUID(GUID);
  Succes := CreateDir(GetTempDir + GUIDToString(GUID));
end.
extern crate tempdir;
use tempdir::TempDir;
let tmp = TempDir::new("prefix")?;
function createTempDir(): ?string
{
    $separator = DIRECTORY_SEPARATOR;
    $path = rtrim(sys_get_temp_dir(), $separator) . $separator . mt_rand() . microtime(true);
    $createdTempDir = mkdir($path);
    if ($createdTempDir) {
        return $path;
    }

    return null;
}
import System.IO.Temp
withTempDirectory $ \d -> do
  -- do something with d
use Path::Tiny qw(tempdir);
my $path = tempdir;
using System.IO;
string newDir = Path.GetTempPath() + Guid.NewGuid();
Directory.CreateDirectory(newDir);